Automated Control System

The chromatography workstation applies mature DCS distributed control strategy to manage pumps, valves and different online detectors and collect related data. It supports multi‑column series‑parallel combination operations and helps maintain steady and consistent processing status.

A dedicated online detection system is configured for traditional‑Chinese‑medicine processing.

The system monitors regular process parameters including flow rate, pressure, temperature, optional pH value and conductivity. Optional ultraviolet spectroscopy and near‑infrared spectroscopy can be deployed to test the content of effective components from traditional Chinese medicine in real‑time.

Chromatography Column Structure

The chromatography column adopts well‑planned structure with appropriate height‑to‑diameter ratio and well‑matched inlet‑outlet flow distributors. It is fitted with an automatic packing system and compressed‑air interfaces to secure acceptable filling status and packing regeneration performance, supporting steady separation performance.

This unit is developed for medium‑and‑large‑scale purification of target compounds within pharmaceutical industries. Preparative liquid‑chromatography columns allow relatively high sample loading capacity and support mass‑preparation of purified products with reasonable production‑cost levels.

Functions and Features

This system is applied in wastewater‑treatment projects and the extraction and purification of proteins, enzymes, monosaccharides, polysaccharides and plant‑derived active ingredients. Chromatographic separation runs under mild working conditions at room‑temperature and conventional atmospheric pressure. Several purified ingredients can be collected after one‑time material feeding. Suitable separation settings help obtain products with qualified purity. The unit adopts modern computer‑automated control and online process‑parameter monitoring technologies to optimize conventional manual‑operated chromatography devices for better operational stability and repeatability. The equipment supports scale‑up deployment for industrial‑production scenarios.

Chromatographic Separation Techniques for Natural‑Product Isolation and Purification

Adsorption chromatography and ion‑exchange chromatography are widely‑adopted separation approaches for processing traditional‑Chinese‑medicine ingredients. Adsorption chromatography includes reversed‑phase chromatography with C18 packing materials and normal‑phase silica‑gel chromatography. Ion‑exchange chromatography works well for isolating charged compounds. At present, chromatographic separation methods gain wider application for refining active components from traditional Chinese‑medicine such as flavonoids, alkaloids, glycosides, organic acids and polysaccharides.

Application Scenarios of Natural‑Product Separation and Purification

It serves for small‑scale process development, pilot‑process amplification, and preparation of phytochemical reference substances. It can isolate phenols, aldehydes, alkaloids, amino acids, steroids, terpenes, flavonoids, quinones, organic acids, glycosides, saccharides and nucleosides. Typical examples include paclitaxel, tea polyphenols, ginkgo flavonoids, bamboo‑leaf flavonoids and Vitamin‑E.